PEPCK regulates antiepileptic and anticonvulsant effect of 2-deoxyglucose (2-DG)
Figure 4   Inhibition of PEPCK prevents the anti-epileptic effect of  glycolytic inhibitors.  A)  3-MCP increases baseline bursting to 234 +/13% of base line.  Addtion of 2-DG and lactate does not slow the rate of  bursting but slightly increases it to 296+/- 17% of the baseline frequency (n=6).    B)  Iodacetate and lactate do not slow the rate of bursting in the presence of  3-MCP.   3-MCP alone increases the rate to 232 +/-44% of basline and it is increased to    344+/-76 in the presence of iodoaceatate and lactate (n=4).
PEPCK regulates antiepileptic and anticonvulsant effect of inhibiting glycolysis
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Copyright 2011 Steve Kriegler