Figure 5.  The effect of substrates for PEPCK on epileptiform bursting.  A) Addition of oxaloacetate to slices in which glycolysis is not blocked reduced burting to 70 +/- 6 percent of control.  B)Alternative substrates for PEPCK that hydrolyze GTP to GDP, glycolic acid, b-chlorolactate and thiolactate also reduce epileptiform bursting to 77 +/-5  58 +/- 6 and 50 +/-6   % of control respectively (p<0.05 for all).  C) This antiepileptic effect of substrates for PEPCK is blocked by 3-MCP.

A

B

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Copyright 2011 Steve Kriegler

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