Figure 5. The effect of substrates for PEPCK on epileptiform bursting. A) Addition of oxaloacetate to slices in which glycolysis is not blocked reduced burting to 70 +/- 6 percent of control. B)Alternative substrates for PEPCK that hydrolyze GTP to GDP, glycolic acid, b-chlorolactate and thiolactate also reduce epileptiform bursting to 77 +/-5 58 +/- 6 and 50 +/-6 % of control respectively (p<0.05 for all). C) This antiepileptic effect of substrates for PEPCK is blocked by 3-MCP.
Copyright 2011 Steve Kriegler